7:00 AM - 7:45 AM
Staying Young Through Hormonal Balance
Edwin N. Lee, M.D., FACE
Assistant Professor of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL
Founder, Institute for Hormonal Balance
Member, AMMG Conference Planning Committee
Non-CME Symposium Sponsored by STARx Pharmacy
(Open to all attendees and includes complimentary breakfast)
8:00 AM - 8:50 AM
Integrative Cardiology for the Age Management Specialist: Identification and Nutraceutical Management of Emerging Cardiovascular Risk Factors
Mark P. Menolascino, M.D., MS, ABIHM, ABAARM, IFMCP
Medical Director, Meno Clinic, Center for Advanced Medicine, Jackson Hole, WY
Lecture Description:
A unique and individualized state of the art approach at cardiovascular prevention and treatment. With the recent FDA black box warning on all statin drugs for dementia, depression and diabetes we must focus on the Number Needed to Treat for making rational decisions for who benefits from targeted therapy. We will review the studies looking at targeted therapies and provide an algorithm for physicians to identify and manage the high risk clients. Furthermore, our goal as Age management Medicine Physicians is to provide a preventive strategy to guide your patients towards avoidance of stroke and heart attack. This lecture will give you a thorough understanding of current biomarkers of risk, future insights into additional age management medicine tools for prevention to allow you the opportunity to provide cutting edge prevention and treatment strategies that will impress your patients and provider superior medical care.
8:50 AM - 9:35 AM
HRT in Women and Prevention of Cardiovascular Disease
Cesar M. Pellarano, M.D.
Preventive Cardiologist, Miami, FL
President, Founding Partner and Chief Medical Officer, Hillstar Health LLC, Miami, FL
Lecture Description:
Cardiovascular Disease is the number one killer in women who die of heart attacks and strokes more than their male counterparts. This is despite the fact that cardiovascular disease is more prevalent in men. Female hormones play a key role in Cardiovascular risk for women. The management of these hormones is critical both in preventing cardiovascular disease or increasing the risk. This lecture will highlight the steps for preventing cardiovascular disease in women, and the hormone replacement therapy.
9:35 AM - 10:30 AM
Cardiovascular Disease in Women: Epidemiology and Prevention - Gender Differences in Prevalence and Outcomes
Charles L. Schulman, M.D., FACC
Assistant Clinical Professor of Medicine, Harvard Medical School, Boston, MA
Senior Physician, Beth Israel-Deaconess Medical Center, Boston, MA
Lecture Description:
Lecture will review gender differences in prevalence and outcomes of CVD and review the AHA 2011 updated guidelines for CVD prevention in women.
10:30 AM - 10:45 AM
Break
10:45 AM - 11:30 AM
The Endothelial Glycocalyx: Early Marker and Therapeutic Target of Vascular Complications
Hans Vink, Ph.D.
Professor of Circulatory Physics, University of Amsterdam, The Netherlands
Associate Professor of Physiology, Maastricht University, The Netherlands
Chief Science Officer, GlycoCheck BV
Lecture Description:
The innermost lining of blood vessels is formed by endothelial cells, and recent studies have demonstrated that many interactions between blood components and the vascular wall are mediated by the endothelial glycocalyx, a complex mesh of proteoglycans, glycosaminoglycans and plasma proteins that is anchored to the plasma membrane of vascular endothelium. Due to its strategic position, its molecular and mechanical barrier properties and its estimated dimension of about 1 µm thick, the glycocalyx protects the healthy vessel wall against transendothelial leakage of plasma molecules, endothelial adhesion of platelets and leukocytes, and mechanical damage by stimulating endothelial production of the vasodilator nitric oxide in response to increased levels of fluid shear stress. Recent studies have established that the glycocalyx is perturbed by hyperglycemia and in diabetes. These findings led to the concept that (hyperglycemic) damage to the glycocalyx marks an increased pathogenic risk in diabetes, while prevention of glycocalyx loss or restoration of glycocalyx protective properties might be a possible therapy against acute or chronic diabetic vascular complications. We recently developed a clinical intravital microscopic approach for standardized assessment of microvascular glycocalyx dimensions, allowing us to evaluate glycocalyx dimensions and associated vascular parameters in healthy controls and humans with type 2 diabetes mellitus.
Furthermore, we will report on the contribution of glycocalyx damage to vascular complications and kidney function and our recent findings on the potential of glycocalyx restoration strategies to repair experimental endothelial barrier properties and support clinical vascular health.
11:30 AM - 12:20 PM
Update on Cardiovascular Risk Factors and Cardiopulmonary Capacity in 200 Men Undergoing an Age Management Program
Ernst R. Schwarz, M.D., Ph.D.
Professor of Medicine, Cedars Sinai Medical Center at UCLA
Lecture Description:
The results of a commercially available age management program on effects on cardiovascular capacity and cardiovascular health are presented. 200 self-referred male patients were analyzed. All fulfilled criteria of obesity, partial androgen deficiency, and sedentary life styles. A dietary and exercise regimen under supervision of a physician was initiated in conjunction with testosterone substitution if clinically indicated. At one year follow up, cardiac capacity improved significantly, body weight was reduced and muscle mass increased without serious adverse events. The program appeared safe as long as physician supervision was provided.
12:00 PM - 7:00 PM
Exhibits Open
12:20 PM - 1:30 PM
Lunch Break
Available for purchase in exhibit area
1:30 PM - 2:15 PM
Early Detection of Cardiovascular Disease: Relationship of Endothial Dysfunction to Cardiovascular Events
Dennis A. Goodman, M.D., FACC, FACP, FCCP
Clinical Associate Professor, NYU
Director, Integrative Medicine, New York Medical Associates
Steven M. Villagomez, M.Ed.
Exercise Physiologist, ComiteMD Center for Precision Medicine, New York, NY
Clinical Instructor & Assistant Professor, Exercise Physiology Graduate Program, Long Island University
Lecture Description:
Decades prior to a cardiovascular event, there may be manifestations of subclinical atherosclerosis including endothelial dysfunction. Left untreated patients may present later with a myocardial infarction, stroke or SCD. We will discuss methods to identify the high-risk individual, how to monitor them and intervene aggressively and prevent these adverse outcomes. Specifically, we will address current modalities in diagnostic approaches, including an office-based technology that allows for assessment and current function of the endothelium by the age management physician.
2:15 PM - 3:05 PM
Nitric Oxide Deficiency & Restoration: New Discoveries in Cardiovascular & Sexual Health
Nathan S. Bryan, Ph.D.
Professor, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
Lecture Description:
Nitric oxide (NO) is a multifunctional signaling molecule, intricately involved with maintaining a host of physiological processes including but not limited to host defense, neuronal communication and the regulation of vascular tone. The endothelium-derived NO plays a crucial role in regulating a wide spectrum of functions in the cardiovascular system, including vasorelaxation, inhibition of leukocyte-endothelial adhesion, vascular smooth muscle cell (SMC) migration and proliferation, as well as platelet aggregation. In this regard, NO is a potent vasodilator as well as a powerful anti-platelet and anti-leukocyte factor. NO is one of the most important signaling molecules in our body. Loss of NO function is one of the earliest indicators or markers of disease. Experimental and clinical studies provide evidence that defects of endothelial NO production, referred to as endothelial dysfunction, is not only associated with all major cardiovascular risk factors such as hyperlipidemia, diabetes, hypertension, erectile dysfunction, smoking and severity of atherosclerosis, but also has a profound predictive value for future atherosclerotic disease progression. Emerging published literature reveals that NO insufficiency may manifest itself differently in different patients but first presents primarily as sexual dysfunction in both men and women.
Thirty plus years after its discovery and over 12 years since a Nobel Prize was awarded for its discovery, there have been no hallmark therapeutic breakthroughs. We will review the current state of the science surrounding nitric oxide in the etiology of a number of different disease states and reveal the latest technology to safely and effectively restore nitric oxide in patients. The audience will learn the challenges and opportunities that exists in understand NO homeostasis in their patients and how this may translate into better management of their patients.
3:05 PM - 3:50 PM
Break - Visit Exhibits
3:50 PM - 4:40 PM
Genetic Markers of Cardiovascular Disease
H. Robert Superko, M.D., FACC, FAHA, FACC
Clinical Professor, Mercer University School of Pharmaceutical Sciences, Atlanta, GA
VP, Chief of Medical Affairs, Celera Corporation, Alameda, CA
Lecture Description:
Cardiovascular disease (CVD) remains the leading cause death in the USA. CVD is now considered to be an interaction between genetic susceptibility and environmental lifestyle issues. Practical clinical utility of inherited cardiovascular risk testing does exist utilizing both phenotypes and genotypes and includes improved CHD risk prediction and early CHD detection, selection of a treatment most likely to be successful in an era of personalized medicine includes genetic susceptibility and the clinical role of currently available tests. Dr. Superko will also discuss the practical implications of genetic tests including 9p21, 4q25, SLCO1B1, ApoE, and others.
4:40 PM - 5:30 PM
Inflammatory Markers of Cardiovascular Disease
Dharmesh S. Patel, M.D., MBBS, FACC
Practicing Physician, The Stern Cardiovascular Foundation, Memphis, TN
Please note: This lecture was originally scheduled to be delivered by Dr. Mark Penn, who had to withdraw for personal reasons after materials were already printed. Dr. Dharmesh Patel has kindly stepped in and will be utilizing Dr. Penn's presentation.
5:30 PM - 7:00 PM
AMMG Welcome Reception
Open to all conference attendees, spouses and guests
Held in Conference Networking and Exhibits Center
7:00 AM - 7:45 AM
Staying Young Through Hormonal Balance
Edwin N. Lee, M.D., FACE
Assistant Professor of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL
Founder, Institute for Hormonal Balance
Member, AMMG Conference Planning Committee
Non-CME Symposium Sponsored by STARx Pharmacy
(Open to all attendees and includes complimentary breakfast)
8:00 AM - 8:50 AM
Clinical Use of Supplements in the Age Management Practice
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
Lecture Description:
Estimates are that 70% of the U.S. population is using some type of “Integrative Medicine”. Supplement use by our patients is above 50%. During the presentation we will discuss the safe and best way for the clinician to direct their patients on the use of supplements.
8:50 AM - 9:40 AM
Nutrient Strategies for the Age Management Clinician
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
Lecture Description:
Basic nutrients are critical to better health. The safe use of these nutrients in clinical practice is even more critical. How clinicians inform their patients on the safe use of these supplements needs to be part of their daily routine. During this presentation we will review some of the basic strategies the physician can use to make patients in their practice, and the public in general, aware that what they are doing is not only beneficial but safe.
9:40 AM - 10:30 AM
Assessing the Age Management Patient
C.B. Daniel, M.D.
CEO & CMO, Cenegenics, Phoenix, AZ
Lecture Description:
What is the current evidence based approach to the initial clinical assessment of the age management patient? How has the clinical evaluation evolved over the last several years and where is it headed in the future? What are the current diagnostic tools we have available to evaluate and to monitor patients in age management medicine? What is our relationship to our traditionally practicing medical colleagues? How do we understand what our roles and responsibilities are to our patients in age management medicine?
10:30 AM - 10:45 AM
Break
10:45 AM - 11:45 AM
The Use of Fitness in the Clinical Age Management Practice: Assessing the Patient and Developing Individualized Treatment Plans
Shahab Mokhtare, M.D.
Partner, Cenegenics, Las Vegas, NV
Lecture Description:
A systematic review of the effects of customized training interventions on measures of functional outcomes in healthy older adults. The importance of assessing the patient, categorizing them based on strength and cardiovascular ability, and developing an individualized treatment plan will be reviewed. We will further analyze a case study of a 49-year-old former natural competitive body builder who presented with visceral adiposity, joint pains, decreased energy and diminished libido.
11:45 AM - 12:15 PM
The Science of Telomere and Age Management
Earl H. Eye, M.D., FACCP
President, Cenegenics, Jacksonville, FL
Lecture Description:
Learn what are telomeres, how they function, what association they have with disease, how to detect shortening, and potential interventions. I will present a case of a 51-year-old white female who is very compliant with our program and had virtually perfect labs except for a slight insulin elevation. She will illustrate why testing is important. I will discuss what we can do to 1) Discover short telomeres, and 2) Measures to lengthen short telomeres.
12:00 PM - 7:00 PM
Exhibits Open
12:15 PM - 1:30 PM
Lunch Break
Available for purchase in exhibit area
1:30 PM - 2:30 PM
Introduction to HRT in Women: Do Natural Hormones Live Up to Their Claims of Protection Against Deterioration and Illness
Neal Rouzier, M.D.
Director, The Preventive Medicine Clinics of the Desert, Palm Springs, CA
Lecture Description:
This presentation is a review of some of the scientific data and studies demonstrating the beneficial effects of hormones and the health detriment that occurs when hormone levels fall. Scientific studies support which hormones are beneficial and which hormones should be avoided. These studies are all peer-reviewed, evidence-based studies that ACOG and NAMS chose to ignore yet are of utmost importance for physicians as well as patients in determining which hormones are safe and preferable. Therefore the literature very adequately demonstrates a superiority of bioidentical hormones over their synthetic hormone counterparts, particularly when it pertains to breast cancer protection and cardiovascular protection. However physicians must uphold the scientific standards presented in these articles in order to guarantee efficacy. Any smaller dosing than that used in medical studies, inadequate monitoring, or inappropriate, non-therapeutic serum levels of hormones may predispose one to harm due to hormone deficiency. Physicians therefore must assure adequate levels of hormones in order to assure efficacy similar to what is seen in our medical literature. Out of the many studies reviewed, no study involves the use of compounded bioidentical HRT; rather these studies utilize only pharmaceutical FDA approved bioidentical hormones in standardized doses monitored with serum testing. Emphasis will be on utilizing the same hormones at the same doses which achieve the same levels which
will then attain the same results as the scientific literature supports. The best method for assuring efficacy of a treatment should be through medical studies and medical literature which is the only sensible way of establishing an evidence-based approach to our therapies.
2:00 PM - 7:00 PM
Exhibits Open
2:30 PM - 3:30 PM
Introduction to HRT in Men: What All Clinicians Should Know About HRT for Men, But Don’t
Neal Rouzier, M.D.
Director, The Preventive Medicine Clinics of the Desert, Palm Springs, CA
Lecture Description:
There is no other therapy that physicians can offer that has the impact and importance in improving how we feel and function as does hormone replacement, and this applies to both men and women. There is no other therapy that has the long term studies and literature support for improving longevity and decreasing the diseases of aging which can lead to deterioration in our function and ultimate demise. The purpose of this lecture is several-fold. Using the medical literature, we will come to understand the importance of all hormones for both men and women and the detrimental effects of hormone depletion. Secondly, there are many different hormones of importance in both men (testosterone, thyroid, DHEA). Thirdly, a review of our literature will demonstrate surprising benefits of hormones that most physicians remain unaware of: All of the hormones listed have well documented protective effects on all of our organs, tissues, and aesthetics, all of which are important to any cosmetic or preventive medicine practice. There is not one surgical procedure that can affect skin thickness, wrinkles, collagen, muscle tone, subcutaneous fat, visceral fat mass, improve longevity & health, plus improve our quality of life and well-being. However this is precisely what hormone replacement can accomplish. Sound too good to be true? Well let’s examine the evidence based medical literature to get an understanding of the science that supports this and why men too demand HRT.
3:30 PM - 4:15 PM
Break - Visit Exhibits
4:15 PM - 4:45 PM
The Science of Stem Cells and Age Management Medicine
Christopher Centeno, M.D.
Medical Director, Centeno-Schultz Clinic, Broomfield, CO
Member, AMMG Conference Planning Committee
Lecture Description:
Recent research has implicated that adult stem cells play a role in aging. Other research has shown that aging can negatively impact the health of adult stem cells. Various strategies to revive aged adult stem cells will be presented.
4:45 PM - 5:30 PM
The Science of Genetics and Genetic Testing and Age Management Medicine
Florence Comite, M.D.
CEO & Founder, Comite Center for Precision Medicine, New York, NY
Member, AMMG Conference Planning Committee
Lecture Description:
Genetic screening is increasingly available; it is a natural extension of Age Management Medicine. Obtaining the genetic make-up of individuals can help to identify potential disorders of aging. However, the genetic blueprint is not absolute, nor is it a predestined outcome. Since this is rapidly being actualized in practice, the clinician should be comfortable with the interpretation of genetic testing and the value of diagnostic screening. Patients deserve a solid understanding of the relationship between their genes and disorders of aging. It is vital that the clinician is prepared to balance, discuss, and position the possible outcomes in relaying test results. Overall, screening adds much to our ability to identify underlying influences that might tilt the scales toward various disorders of aging. At the same time, it strengthens our ability to manage and motivate successfully. Further, it allows the clinician to set interventional priorities and weigh the risk-benefit scale of options. This leads to more precise guidance with respect to subsequent diagnostic tests and procedures as well as interventions, ranging from lifestyle to supplements and medications.
5:30 PM - 7:00 PM
AMMG Welcome Reception
Open to all conference attendees, spouses and guests
Held in Conference Networking and Exhibits Center
7:00 AM - 7:45 AM
Estrogen in Men: An Update
Neal Rouzier, M.D.
Director, The Preventive Medicine Clinics of the Desert, Palm Springs, CA
Non-CME Symposium Sponsored by MedQuest Pharmacy
(Open to all attendees and includes complimentary breakfast)
8:00 AM - 8:05 AM
Opening Remarks
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
8:05 AM - 9:00 AM
21st Century Plague: "Modernized" Food and Its Collateral Damage
Arden B. Andersen, D.O., Ph.D., MSPH
Medical Director, Crossroads Healing Arts, Goshen, IN
Professional Food Production Consultant - Author - Instructor
Lecture Description:
Age management doctors strive to find the latest in scientific medical approaches to health and longevity. We pride ourselves on the scientific literature substantiating our patient care, but unfortunately few providers realize the same scientific citation exists regarding the potential direct carcinogenicity and endocrine disruption of the "food" they recommend to their patients. Genetic engineering of food over the past 20 years has resulted in not only significant pesticide use increase around the world along with rampant proliferation in resistant disease and weed organisms, it has resulted in statistically significant, documented animal health decline and infertility. Most importantly the most recent animal study by Seralini et al shows direct causation by genetically engineered food of cancerous tumor, kidney and liver disease. This trumps any supplement or HRT program the doctor recommends. If doctors are going to recommend dietary programs they need to know the potential consequences of their recommendations and be able to advise patients of appropriate food choices and avoidances.
9:00 AM - 9:50 AM
Assessing the Gut Microbiome to Maintain Optimal Health
Todd R. LePine, M.D.
Private Practice Internal Medicine, Stockbridge, MA
Staff Physician, UltraWellness Center, Lenox, MA
Lecture Description:
Though health is commonly perceived as ‘the absence of illness,’ considerations of optimal health for many of us – especially as we grow older – expand this definition to ‘optimal functioning in all phases of life.’ As a clinical approach for patients, supporting this optimal functional capacity begins before the onset of disease and considers biochemically unique factors to optimize individual health, through assessment, prevention, and treatment. The human gastrointestinal system plays a key role in this optimal functioning capacity via its microbiota which are engaged in myriad metabolic, nutritional and immune processes. In addition, studies increasingly suggest that the each individual’s gut microflora composition and activity influence host resiliency and disease development. In this presentation, we will consider the individual evolution of the human gut microbiome, as well as the variety of factors that impact its activity and composition: Diet, stress, age, and the health status of the host. We will frame an understanding of the health of the gut through the lens of specialty diagnostics that reveal microbial populations, balance and metabolism, and discuss how such tools can support personalized patient care throughout the lifespan.
9:50 AM - 10:30 AM
Break - Visit Exhibits
10:30 AM - 11:25 AM
Nutraceutical Approach in Chronic Liver Disease: Myths, Facts and Drawbacks
Francesco Marotta, M.D., Ph.D.
Co-Director, ReGenera Research Group for Aging Intervention, Milan, Italy
Hon. Research Professor, Dept. Human Nutrition, Texas Woman’s University, Denton, TX
WHO Collaborating Centre for Traditional Medicine-Biotechnologies, State University of Milan, Italy
Lecture Description:
The uncontrolled growth of self-medication makes integrative medicine in chronic liver disease worth great scientific consideration and caution too. Indeed, some substances may turn to be hepatotoxic while the scientific evidence is still a bit scattered making this field rather blurred. Upon completion of the presentation, the physician should be able to have a wider look on the field of “liver-protection”, understanding what experimental and clinical evidence suggest, how to apply this knowledge in a coordinated therapeutic strategy.
11:25 AM - 12:15 PM
HIV and Aging: Important Considerations For Those In Care and Those Unaware
Susan C. Ball, M.D., M.P.H., M.S.
Associate Professor of Medicine, Associate Professor of Public Health, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, NY
Lecture Description:
With effective therapy for the treatment of HIV, infected patients in care can expect to live long and healthy lives. The CDC anticipates that by 2015 over half those infected with HIV in the United States will be over the age of fifty. This presents a new set of challenges for patients and providers. Recognizing risk and getting patients into care is crucial for better management of HIV disease. Fewer HIV-infected patients die of AIDS-associated causes but HIV can accelerate or exacerbate age-related conditions such as cardiovascular disease or renal insufficiency. This lecture will focus on raising awareness of HIV risk and discuss pertinent co-morbidities in the HIV-positive aging population.
12:15 PM - 1:15 PM
Physician Opportunities in Age Management Medicine: Your Path to a Successful Age Management Medicine Practice
John E. Adams
President and CEO, Cenegenics
Non-CME symposium sponsored by Cenegenics Medical Institute
(Open to all attendees and includes a complimentary lunch)
12:15 PM - 1:30 PM
Lunch Break
1:30 PM - 2:20 PM
Using an Enhanced Elimination Diet for Fast & Lasting Fat Loss
JJ Virgin, CNS, CHFS
Nutrition and Fitness Expert, Best Selling Author
Adjunct Professor, Bauman College
Lecture Description:
When patients want to lose weight, they want to lose weight now and quickly. A recent study revealed that those who lose weight quickly actually lose more weight overall and keep more of that weight loss off. An enhanced elimination diet is a great fast weight loss tool as it induces fast weight loss, reduces cravings and removes the “cheat factor” inherent in every diet. After the initial elimination phase, foods are rechallenged to create a customized long term eating program that will support continued weight loss and promote better health overall. To keep the weight off long term, there are different strategies required to maintain weight loss that most be incorporated into a maintenance program.
2:20 PM - 3:00 PM
Nutritional Management of Diseases of Overt Inflammation: Impact on Cancer and Diabetes
Okezie I. Aruoma, MBA, Ph.D., D.Sc., CChem., FRSC
Professor of Pharmaceutical and Biomedical Sciences; Associate Dean, Research and Global Affairs; Chair, AUHS Institution Review Board, American University of Health Sciences, Signal Hill, CA
Lecture Description:
Chemotherapy to patients with cancer remains an effective mode of treatment of the disease, but it is associated with many side effects including mild or dose-limiting toxicities such as alopecia, myelosuppression, gastrointestinal dysfunc¬tions, neurologic toxicities, and immune suppression which results in infections and cancer cell proliferation. Although economic analysis of treatment in health care systems may be applied to the full range of interventions that make up a cancer service, the economic impact of cancer in health care systems remains one that much attention, in the context of complementary medicine. The constituent phytochemicals, mainly phenolic compounds may play a crucial role in health promotion and disease prevention by exerting by acting as antioxidants and/or via a variety of other mechanisms related to cell differentiation, deactivation of pro-carninogens, maintenance and optimization of DNA repair machinery. Elucidation of the intracellular pathways associated with free radicals is essential in order to gain insight into the pathophysiologic basis for oxidative stress. Additionally, the outcome of recent clinical trials using tea and fermented papaya preparation suggest that their significant effects on markers of inflammation plasma uric acid and C-reactive protein levels may not only benefit individuals at high risk of cardiovascular events but augment prescription drug therapy.
This will ultimately define whether chronic administration of antioxidant nutraceuticals and/or functional foods may have beneficial prophylactic potential in the management of diseases with overt inflammation.
3:00 PM - 3:30 PM
Break - Visit Exhibits
3:30 PM - 4:20 PM
Thyroid Assessment – Blood or Reflexes?
Daryl Turner, BSc(Hons.), MBA(H.Hons.), Ph.D.
Chief Operating Officer, NiTek Medical, Scottsdale, AZ
Lecture Description:
In the years past for thyroid disease, doctors traditionally looked at the symptoms, the reflexes etc., to help dose to what they felt the ‘normal’ thyroid function should be (the amount of thyroid given, on average was three times higher than seen today). Patients on natural desiccated thyroid meds before 1970 felt more motivated, more energy, and noticed that they overall felt better! In the 1970’s, there was a change in thyroid treatment with the introduction of synthetic thyroid hormones and the changeover to looking at TSH for the basis of diagnosing the condition of thyroid disease. TSH is the wrong marker; it plays a role, but it has created a new group of patients, who are categorized into the “subclinical hypothyroid” group. This is a very large group of patients that repeatedly tell their doctors, “I have all of these symptoms, I’m cold all the time, lethargic, tired, constipated, hair is falling out, low sex drive, gaining weight, I’m depressed, my mood changes easily…” and they are told take an antidepressant or other drug, go on a diet, etc.!!! They are totally ignored basically, due to experiencing “Subclinical Hypothyroidism” in their lives, and not having it treated. The diagnosis of blood is not complete to cover this group. If your thyroid is slightly out, not only does it play havoc with your other hormones, but it can lead to a whole array of other long term illnesses, such as psychiatric syndromes, neurological problems,
cognitive deficits, skeletal syndromes, diabetes, heart disorders, pregnancy complications, insomnia, and double the chance of Alzheimer’s.
In 1971, Dr. R.I.S. Bayliss, a famous Endocrinologist, stated the following after many decades of treating thyroid conditions: “I am often asked how the correct dose of thyroxine is determined. The answer is clinically by the patient’s pulse rate, his sense of wellbeing, the texture of his skin, his tolerance of cold, his bowel function, and the speed with which his deep tendon reflexes relax. Is thyroid not the hormone capable of raising the constitution and well-being of the patient? Anyone can be brought up to the top of their constitutional capabilities when tested adequately for thyroid hormone. This would only be done by clinical assessment, not blood tests; there is no relation between the signs and symptoms of low thyroid disease, the TSH, or the other related blood tests.”
In the year 2000 we decided to tackle the Thyroid Question. We all learned in medical school that reflexes speed up and slow down with thyroid function. There had been some attempt in the 60’s to look at measuring the deep tendon reflex that resulted in the development of the Photomotogram. We decided to look at the reflex speeds once more, and after many trials and failures, developed a testing device, called the Thyroflex. The Thyroflex measures the speed of the neurotransmitters, the reflex speed and integrates that information into a resting metabolic rate along with the symptoms, and prints out the results. This gives you, the physician, detailed information for the treatment of the patient that is totally accurate, fast, and easy to interpret in real-time, and it is non-invasive, and is instantly available as you talk to the patient.
4:20 PM - 5:30 PM
Where is Age Management Medicine Going with 21st Century Medical Science: Short Presentations and Panel Discussion of Innovations in Telomere, Genetic Testing and Stem Cells
Robert D. Willix, Jr., M.D.
CEO, President, Enlightened Living Medicine, Boca Raton, FL
Christopher Centeno, M.D.
Medical Director, Centeno-Schultz Clinic, Broomfield, CO
Member, AMMG Conference Planning Committee
Florence Comite, M.D.
CEO & Founder, Comite Center for Precision Medicine, New York, NY
Member, AMMG Conference Planning Committee
Earl H. Eye, M.D., FACCP
President, Cenegenics, Jacksonville, FL
Marc S. Penn, M.D., Ph.D., FACC
Director of Research, Summa Cardiovascular Institute
Professor of Medicine and Integrative Medical Sciences, Northeast Ohio Medical University
Co-Founder and Chief Medical Officer, Cleveland Heart Lab
Founder and Chief Medical Officer, Juventas Therapeutics, Inc.
7:00 AM - 7:45 AM
Case Study: A Successful Age Management Practice
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Non-CME Symposium Sponsored by PhysioAge
(Open to all attendees and includes complimentary breakfast)
8:00 AM - 8:50 AM
Botanical Selective Estrogen Receptor Modulation – Balancing Sex Hormone Metabolism for an Aging Population
Joseph J. Lamb, M.D.
Director of Intramural Clinical Research for the Functional Medicine Research Center,Metagenics, Inc in Gig Harbor, WA
Lecture Description:
This lecture will consist of the following segments: (i) Overview of hormonal changes in men and women as they age. I will describe menopausal symptoms and their impact on women’s quality of life as well as men’s prostate health and concerns. (ii) Pharmacological treatments for menopausal symptoms (particularly hormone replacement therapy) and prostate problems. Their benefits, risks, limitations and contraindications will be discussed. (iii) “Natural”, botanical remedies for hormonal imbalances. I will review the scientific evidence, proposed mechanism(s), benefits and limitations of various compounds including Isoflavones, red clover , black cohosh and Traditional Chinese Medicines. (iv) Phytoestrogens that modulate Estrogen Receptor (ER) ß. I will briefly describe the selective estrogen-receptor modulators and the difference between ERa and ERß. This segment will focus on the recent scientific findings of hydroxystilbenes (e.g. rhaponticin, desoxyrhaponticin, rhapontigenin, and desoxyrhapontigenin) found in Rheum rhaponticum L. I will discuss their clinical study highlights and their proposed biological mechanisms. (v) Lifestyle changes for better quality of life during this life transition. I will recommend lifestyle choices that may help older men and women better manage hormone-related concerns during this transition.
8:50 AM - 9:40 AM
Andropause: Fact or Fiction?
Jeffry S. Life, M.D., Ph.D.
Clinic Physician, Apeiron, Charleston, WV
Board Certified, Family Medicine
Diplomate, American Board of Family Practitioners
Fellow, American Academy of Family Physicians
Lecture Description:
This presentation dispels the belief held by many traditional medical institutions and societies that andropause does not exist and should not be treated. I describe the vast amount of recent peer reviewed studies that make it clear that for physicians to ignore androgen deficiency means they are harming their patients.
9:40 AM - 10:20 AM
Break - Visit Exhibits
10:20 AM - 11:15 AM
Adult Growth Hormone Deficiency
Edwin N. Lee, M.D., FACE
Assistant Professor of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL
Founder, Institute for Hormonal Balance
Member, AMMG Conference Planning Committee
Lecture Description:
Growth hormone is an essential hormone in lowering body fat, improving on lipids, keeping muscles healthy and improving on bone density. These—and other benefits from the use of growth hormone—will be covered. In addition, adult growth hormone deficiency symptoms will be reviewed, as well as the role of growth hormone deficiency increasing inflammation, and the association of higher mortality with growth hormone deficiency. The normal physiology and role of IGF-1, IGF Binding Protein 3 will be discussed. Clinical trials with recombinant growth hormone will be covered. The diagnosis of adult growth hormone protocols will be reviewed, as will the treatment of recombinant growth hormone, IGF-1 and with IGF-1 and IGF BP-3.
11:15 AM - 12:05 PM
Hormones and Cancer: What All Practitioners Should Know But Don’t – What Are You Doing to Protect Against Cancer?
Neal Rouzier, M.D.
Director, The Preventive Medicine Clinics of the Desert, Palm Springs, CA
Lecture Description:
Ask any woman if hormones cause cancer and they will answer with a resounding, “Yes!” Ask any oncologist if they recommend estrogen in breast cancer survivors and they will answer, “Absolutely not!” Many a male patient has told me that they stopped their testosterone because their doctor scared them into believing that it caused prostate cancer. And we all know that growth hormone causes cancers to grow (that’s why it’s called “growth” hormone because it causes cancers to grow) as per the warning in the PDR. The objective of this lecture is to prove them all wrong. As a matter of fact, the medical literature demonstrates that replacement of hormones is the one best treatment modality to prevent cancer. This literature review provides the clinician with the most recent data to rest assured that HRT not only does not cause cancer but will provide one of nature’s best protections against the development of cancer.
12:05 PM - 1:15 PM
Lunch Break - Visit Exhibits
12:05 PM - 1:00 PM
ROEHR BioG MicroTabs: Personalized Nutrition in the 21st Century
Wolfgang Roehr, CEO, ROEHR Pharmaceuticals, Julian Blumenfeld, M.D., CMO, ROEHR Pharmaceuticals
Non-CME symposium sponsored by ROEHR Pharmaceuticals
(Open to all attendees and includes a complimentary lunch)
1:15 PM - 2:05 PM
Correcting NeuroEndocrine Dysregulation For Enhanced Clinical Outcomes
Chris D. Meletis, N.D.
Executive Director, Institute for Healthy Aging, Portland, OR
Secretary BOD, Dr. John Lee Institute, Clackamas, OR
Lecture Description:
True wellness is gained, maintained and sustained via proper regulatory control of key homeostatic factors that allows the human organism not only to survive but thrive. Identifying and correcting dysregulation of both neurotransmitter and hormonal allows the astute clinician to unravel and demystify complex multifactorial conditions. The latest clinical lab advances and insights into “full body laboratory interpretation” will provide attendees the tools to apply the information shared throughout this presentation immediately in their practices. This discussion will also share novel and yet to be discussed appreciations of the integral role of both the COMT and 5 alpha reductase enzyme pathways as they pertain to disease manifestation due to stress. Utilization of nutraceutical interventions as well and select prescription considerations will also be reviewed.
2:05 PM - 2:55 PM
Not All Hormones Are Created the Same and Not All Hormones Have the Same Use or Act the Same in the Human Body
Erika Schwartz, M.D.
Member, Board of Trustees and Managers, SUNY-Downstate College of Medicine, Brooklyn, NY
President, Evolved Science
Lecture Description:
Hormones are the juice of life. When you are 20 regardless of whether you are a man or a woman, you are full of hormones, you are fertile, diseases are rare and recovery is swift, we are fertile, do not have wrinkles, can get our body weight under control with diet and exercise and we want to have sex. With the aging process, we loose our hormones and along with their loss we start experiencing symptoms that make us feel crummy. We have hot flashes, night sweats, insomnia, irritability, stubborn weight gain, loss of libido, infertility and chronic illnesses like high cholesterol and high blood pressure become the norm. In short we become roadkill. You can try to exercise, change your diet, get some rest and take supplements but unless you address the hormone balance and recreate the environment of your 30s and early 40s, aging will prevail and turn you into an old, chronically ill and unhappy person. There are options for the safe and intelligent use of hormones to decrease the risks brought on by aging but they are not taught in medical school. Understanding there is no class effect in hormones is key to helping patients and making the difference between a borderline life and a vibrant, healthy life. Bioidentical hormones or human identical hormones are a class of hormones that have been in conventional medical use for more than six decades. Hormone formulations and preparations are crucial and they DO affect outcome in both men and women.
The science of hormones is solid and the clinical application and use of hormones in wellness and disease prevention is of utmost importance in the practice of prevention. Understanding the difference between hormones and their application are the key to ideal hormone balancing.
2:55 PM - 3:30 PM
Break - Visit Exhibits
(exhibits close 4:00 PM)
3:30 PM - 4:30 PM
The Use and Safety of Bioidentical Hormonal Replacement Therapy in Women - A Case Study
Edward R. Rosick, D.O., MPH, DABIHM
Chair, Family & Community Medicine Department, Michigan State University College of Osteopathic Medicine
Lecture Description:
The use of bioidentical hormones (bHRT) continues to be a contentious issue in medicine. Proponents of bHRT state the use of bioidentical hormones is a safe and effective way to treat a variety of both pre and post menopausal disorders in women. However, those opposed to the use of bHRT state that there are little to no scientifically via validated studies showing the efficacy or safety of bHRT and therefore, bHRT should not be used in lieu of more commonly accepted synthetic hormones. In this talk Dr. Rosick will highlight, via a case study, the latest literature in the use of bHRT in both pre and post menopausal women. Dr. Rosick will discuss the potential risks and benefits of bHRTs including their impact on cancer and heart disease. Dr. Rosick will also present via his case study the way in which clinicians can incorporate bHRT in their daily practice.
4:00 PM - 4:00 PM
Exhibits Close
4:30 PM - 5:30 PM
Testosterone/Thyroid Optimization Protocol to Determine the Effects of a Short-Term Program on Stem Cell Activity
Christopher Centeno, M.D.
Medical Director, Centeno-Schultz Clinic, Broomfield, CO
Member, AMMG Conference Planning Committee
Lecture Description:
Basic lab research has shown that testosterone supplementation may help stem cells. However, little is known from actual clinical studies how testosterone supplementation for age management impacts adult stem cells. The results of a small pilot study testing the effects of testosterone and thyroid supplementation on bone marrow mesenchymal stem cells will be presented.
7:00 AM - 7:45 AM
Telomeres, Telomerase, and TA-65: What you need to know in 2013
Presented by Joseph Raffaele, M.D.
Non-CME Symposium Sponsored by TA Sciences
(Open to all attendees and includes a complimentary breakfast)
8:00 AM - 9:00 AM
Stable and Unstable Plaque as a Predictor of Unexpected Cardiovascular Events
Joseph Bosiljevac, M.D., Ph.D., FACS
Senior Partner, Cenegenics, New York, NY
Lecture Description:
Data is presented on a series of 50 patients including Doppler velocities, B-mode imaging, arteriograms, and then the path specimen from subsequent carotid endarterectomy.
The purpose of this presentation is to demonstrate plaque characteristics on B-mode sonography and compare this with the pathology specimen. Current availability of advanced blood markers for chronic inflammation can identify patients at risk for plaque rupture. Looking at various operative specimens will support the current thinking of a dynamic process in sudden cardiovascular events. Calcified stable plaque will be compared to soft lipid plaque. A heterogeneous appearance on B-mode imaging can be correlated with intraplaque hemorrhage and unstable plaque. This is most often seen in those patients with symptoms or at risk for a sudden event due to plaque rupture.
Despite a low risk classification according to the Framingham criteria, 25% of patients can still suffer an unexpected cardiovascular event. This data will be expanded to define tests giving useful data to identify patients at risk for an unexpected event, even though they stratify as low risk using current criteria accepted as standard of care in conventional medicine. A good cardiovascular preventive program is a significant component of a quality age-management practice.
9:00 AM - 10:00 AM
Progesterone and the Brain
Angeli Maun Akey, M.D., FACP
Medical Director & Owner, Ageless Medical Solutions, Gainesville, FL
Medical Director & Owner, North Florida Integrative Medicine, Gainesville, FL
Lecture Description:
This presentation reviews the current understanding of progesterone and the brain. From a review of studies performed in animal models on the importance of progesterone and other neuroactive steroids in brain stabilization, to NIH phase 2 and 3 clinical trials of IV progesterone use in acute traumatic brain injury (the “PROTECT” and “SYNAPSE” trials respectively), there is mounting evidence of the importance of progesterone in both men and women. This presentation leads credence to the use of bioidentical progesterone in the luteal phase for treatment of premenstrual syndrome (PMS) and in hysterectomized women for the observed effect of mood stabilization and sleep quality.
10:00 AM - 10:15 AM
Break
10:15 AM - 11:00 AM
Bio-Identical Signaling Therapy: Its Role in Age Management Medicine
Luis Martinez, M.D., MPH
President, Regenera Global, Ponce, Puerto Rico
President, XanoGene Clinic, San Juan, Puerto Rico
Lecture Description:
Reactive Oxygen Species (ROS) are unavoidable products of cellular metabolism and of environmental exposure to toxins. They are implicated in the aging process due to their detrimental and cumulative effects. However, ROS also serve a crucial role as messengers and are able to activate the oxidative response mechanism (ORM) responsible for increased cellular repair. Aging results in a gradual decrease in the body’s own ability to respond to and activate the oxidative response mechanism. Bio-Identical Signaling Therapy is a scientifically proven approach to increase ORM and cellular repair. This presentation will discuss the scientific basis for Bio-Identical signaling therapy, its benefits and its role in Age Management Medicine.
11:00 AM - 12:00 PM
Hormones and Mitochondrial Dysfunction
Scott Fogle, N.D.
Director of Clinical Information and Laboratory Services, Life Extension Foundation, Fort Lauderdale, FL
Lecture Description:
Mitochondria dysfunction is now associated with numerous disease states and few appropriate medications are currently available to support mitochondrial health. Growing scientific evidence supports the use of many nutrients for supporting healthy mitochondria such as CoQ10, carnitine, and lipoic acid. Interestingly, more studies are now linking hormones to proper mitochondria function. The research indicates a symbiotic relationship between hormones and mitochondria, with each helping maintain other. This presentation will examine the details of why optimal hormone levels are vital for good health and anti-aging by focusing on the relationship between hormones and the mitochondria. Certain hormones may be more beneficial and some that are not commonly used may make excellent additions to any hormone optimization program.
12:00 PM - 12:45 PM
Amplifying the Glutathione System for Heavy Metal Detoxification
Christopher W. Shade, Ph.D.
President, Quicksilver Scientific, Lafayette, CO
Lecture Description:
Mediation of metals toxicity is central to Age Management Medicine due to the propensity of metals to generate oxidative stress and inflammation. However, the methods for metals detoxification are often quite challenging for the body and involve toxic substances (e.g. DMSA, DMPS). The glutathione system is the body’s natural metal detoxification system, and that system can be harnessed and amplified for powerful yet safe metals removal. Fortunately, there is an exciting overlap of research showing that certain phytonutrients (plant compounds) have the ability to upregulate the detoxification/chemoprotection systems, including intracellular antioxidant production, through a mechanism called the Keap1/Nrf2 protein. Coupling use of these compounds with advances in liposomal and nanoemulsion delivery of nutritional compounds (e.g. glutathione and lipoic acid) can create powerful natural approaches for body-wide detoxification and antioxidant protection.
12:45 PM - 1:30 PM
Hearing Loss is a Systemic Illness
Martin Finkel, M.D.
Assistant Clinical Professor of Medicine, Mount Sinai Medical Center, New York, NY
Lecture Description:
Hearing Loss has widespread medical implications. There is increased mortality and there is increased morbidity. Our patients with hearing loss have 24/7 hours of increased stress. They are stressed to try to hear what is being said. They are stressed by social isolation. They are stressed by a decrease in information input. They are stressed by society's inclination to dismiss summarily people with hearing loss as being incapable. They have decreased educational opportunities, decreased vocational opportunities and decreased ability to attract the opposite sex.
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